Abstract
Owing to its precise manipulation in nanoscale, DNA as a genetic code becomes a promising and generic material in lots of nanotechnological outstanding exploitations. The nanoscale assembly of nucleic acids in aqueous solution has showed very remarkable capability that is not achievable from any other material resources. In the meantime, their striking role played by effective intracellular interactions have been identified, making these more attractive for a variety of biological applications. Lately, a number of interesting attempts have been made to augment their marvelous diagnostic and therapeutic capabilities, as being integrated with inorganic compounds involving gold, iron oxide, quantum dot, upconversion, etc. It was profoundly studied how structural DNA-inorganic hybrid materials have complemented with each other in a synergistic way for better-graded biological performances. Such hybrid materials consisting of both structural DNAs and inorganics are gradually receiving much attention as a practical and future-oriented material substitute. However, any special review articles highlighting the significant and innovative materials have yet to be published. At the first time, we here demonstrate novel hybrid complexes made of structural DNAs and inorganics for some practical applications.
Highlights
With the advent of advanced and state-of-the-art detection techniques developed, an unsolved and mysterious biomolecular mechanism working on many living organisms have been clearly turned out [1, 2]
We have demonstrated the up-to-date hybrid materials composed of structural DNAs and inorganic compounds at the first time and showed their progresses for many cutting-edge exploitations including some biological applications (Fig. 1)
We discuss a principal feature and application of structural DNA nanotechnologies, followed by a variety of inorganic compounds that can be crossbred with DNA materials
Summary
With the advent of advanced and state-of-the-art detection techniques developed, an unsolved and mysterious biomolecular mechanism working on many living organisms have been clearly turned out [1, 2]. Since 1980s, Nadrian Seeman has firstly introduced a new idea about DNAs’ use for a generic material, well known to be a structural DNA nanotechnology in a technological view [11, 12]. With his indebted and innovative labors, DNA oligonucleotides, which were solely thought to be a genetic code for survival of all living beings in Earth, have been recognized gradually as a polymeric nanostructure with repetitive functional residues. We have demonstrated the up-to-date hybrid materials composed of structural DNAs and inorganic compounds at the first time and showed their progresses for many cutting-edge exploitations including some biological applications (Fig. 1). A type of nanoparticles used commonly as a building block and their characterizations are initially presented in the first section, successively followed by the second topic discussing their hybrid complexes and some related applications
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
