Abstract
Hyaluronidase increases the preventive activity of the sera of rabbits immunized with tetravaccine with respect to the typhoid, paratyphoid B and Sonne dysentery vaccine antigens. Hyaluronidase and hyaluronic acid are harmless in parenteral administration to albino mice. The tetravaccine-hyaluronidase complex is devoid of anaphylactogenic properties, and untoward reactions provoked in response to its administration (as observed on volunteers) are not greater than with the usual tetravaccine. Administration of this complex to man is accompanied by early (within 24 hours after immunization) production of typhois agglugtinins. Lyophilized hyaluronidase gives a 3–4-fold increase of tetravaccine immunogenicity as a whole; typhoid-paratyphoid antigens are activated more than dysentery antigens of tetravaccine.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
