Hyaluronan\u2013binding protein 2 (HABP2) gene variation in women with recurrent miscarriage

Frida Husseini-Akram,Sally Haroun,Lottie Skjöldebrand-Sparre,Helena Åkerud,Signe Altmäe,Anneli Stavreus-Evers,Britt-Marie Landgren,Inger Sundström Poromaa

doi:10.1186/s12905-018-0618-9

Abstract

BackgroundIdiopathic recurrent miscarriage, defined as three or more consecutive miscarriages, is a distressing early pregnancy complication. Although, the etiology of recurrent miscarriage is still unknown, an aberrant regulation of the endometrial receptivity marker hyaluronan-binding protein 2 (HABP2) has been suggested. The objective of the present study was to investigate the effect of genetic variations of HABP2 in women with idiopathic recurrent miscarriage compared to fertile women.MethodsThis study was designed as a case-control study. In total, 165 women who had three or more consecutive miscarriages and 289 fertile women were included in the study. Polymorphisms in the HABP2 gene were analyzed using TaqMan SNP Genotyping Assays. Three polymorphisms in the HABP2 gene, rs1157916, rs2240879 and rs7080536 (Marburg I) were studied.ResultsPolymorphism in HABP2 showed no significant difference in women with recurrent miscarriage compared to fertile women, except for rs1157916 minor A allele that was more prevalent among RM patients (p = 0.058). Significantly higher live birth rate was observed among women with three to four miscarriages compared to those with more miscarriages (p = 0.001).ConclusionsVariations in the HABP2 gene did not seem to be involved in the etiology of recurrent miscarriage, while, the number of previous miscarriages had an impact on the live birth rate.

Highlights

Idiopathic recurrent miscarriage, defined as three or more consecutive miscarriages, is a distressing early pregnancy complication
There is increasing evidence that the endometrium in women with recurrent miscarriage might be more receptive to implantation than in normal fertile controls, and that repeated miscarriage is a result of selection failure in preventing poor quality embryos from implanting, leading to a later recurrent pregnancy loss, repeated miscarriage is a failure to achieve the quality control of bad quality embryos, the so called natural embryo selection [6, 7]
We have consistently identified that hyaluronan-binding protein 2 (HABP2) transcript plays role in endometrial functions, in endometrial receptivity and embryo implantation process [8,9,10,11]

Summary

Introduction

Idiopathic recurrent miscarriage, defined as three or more consecutive miscarriages, is a distressing early pregnancy complication. An earlier study has shown a peak in the distribution of hyaluronan in the stromal compartment during the mid-proliferative and mid-secretory phases of the cycle. This change in hyaluronan deposition and its correlation with the cyclic growth and remodeling of the human endometrium, suggests a major functional role of hyaluronan in this tissue [15]. Having this important role in endometrial functions, HABP2 clearly is a potential candidate for studies of recurrent miscarriage

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