Huntington’s Disease-Emerging Therapeutic Methods and Potential Utilisation of Bacteriophage to Overcome Current Challenges

Abstract

Abstract: Huntington’s disease (HD) is a neurodegenerative trinucleotide repeat disorder resulting from abnormal CAG repeat length within Huntingtin gene (Htt). Onset of the disease usually starts in middle age, with symptoms including chorea, depression, and irritability. There are currently no cure for HD. Current treatments have limited effectiveness and does not target the pathology of the disease, only alleviating symptoms. New therapeutic methods such as CRISPR, antisense oligonucleotides (ASO) and stem cell therapies all offer potential curative and disease-modifying therapies for Huntington’s Disease. However, a major problem for all these new therapeutic methods is their route of administration. Here, I present a brief overview of the recent advancements in bacteriophage engineering and propose a novel solution of using bacteriophages to treat HD.