Abstract
The fetal “programming of adult diseases” has been previously reviewed. The descriptions were comprehensive, dealing with the effects of nutritional deprivation on the development of adult metabolic and cardiovascular diseases. During the past decade, research into this “programming” also expanded to the development of osteoporosis. The present review deals with the imbalance of bone mineral metabolism, “programmed” by maternal/fetal/infantile nutritional deprivation, and is illustrated with a family history from the Budapest Ghetto.
Highlights
Gestational, immediately postnatal, and early infantile nutrition has been recognized as an influential factor in programming adult metabolic diseases
This concept was previously reviewed by Ophir and Oettinger,[1] with a detailed epidemiological review offered by Ben-Shlomo and Kuh,[2] and a further updated review was offered by Hazani and Shasha.[3]
The effects of external stimuli manifest as changes appearing in a “critical period” of gestation—such as the teratogenic effect of thalidomide on limb development, the effect of rubella on cardiac development, or the effect of radiation on brain cell formation
Summary
M.D., F.R.A.C.S., B.A., M.A.1* and William R. B.A., Ph.D.2 1Department of Orthopaedics, Sydney Wolper Jewish Hospital, School of Humanities, University of New England, Armidale, NSW, Australia, and School of Humanities (Program in History of Medicine), University of NSW, Sydney, Australia; and 2School of Humanities, University of New England, Armidale, NSW, Australia
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
