Abstract
Aspects of humoral immunity were studied in 17 dogs with disseminated aspergillosis (16 cases Aspergillus terreus, 1 case Aspergillus flavipes). All dogs had markedly raised serum IgG levels by single radial immunodiffusion (range 1500–6000 mg dl −1). Despite this, serum antibody to A. terreus was demonstrated in only 7 16 cases by agar gel diffusion, 9 16 cases by counter immunoelectrophoresis, 10 16 by ELISA and 11 16 by an indirect immunofluorescence assay. Serum antibody was also detected in 2 5 clinically normal relatives of 2 cases, indicating previous exposure or subclinical infection.
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