Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine.

Yoshifumi Uwamino,Tomoko Arai,Hiromichi Matsushita,Akiko Tanabe,Hiromitsu Yokota,Ayako Shibata,Tomoyasu Nishimura,Toshinobu Kurafuji,Mitsuru Murata,Ho Namkoong,Kenjiro Kosaki,Naoki Hasegawa,Akemi Ohno,Masayo Noguchi,Yasunori Sato,Takashi Yokoyama,Masatoshi Wakui

doi:10.1016/j.vaccine.2023.01.049

Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine.

Yoshifumi Uwamino, Tomoko Arai + Show 15 more

Open Access

https://doi.org/10.1016/j.vaccine.2023.01.049

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Journal: Vaccine	Publication Date: Feb 1, 2023
Citations: 3

Affiliation: Keio University Hospital, International University of Health and Welfare, Keio University

#Dose Of Vaccine #Japanese Healthcare Workers + Show 8 more

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Abstract

Longitudinal data on the immune response from the first dose to several months after the third dose of COVID-19 vaccine are limited. We analyzed the immune response in 406 Japanese healthcare workers who received at least three doses of vaccine. The geometric mean anti-receptor binding domain IgG antibody titers and antigen-stimulated T-cell interferon-gamma levels after 6months after receiving a third dose were similar to those 8weeks after receiving a second dose. Humoral and cellular immunity induced by the third dose was more durable than that induced by the second dose. UMIN Clinical Trials Registry ID: UMIN000043340.

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