Abstract
Chromatographic profiles of the conjugates of 17α-ethynylestradiol (EE 2) were obtained from the urine of castrate and normal women given tritium labeled EE 2 orally. Five distinct radioactive peaks were observed, with considerable quantitative variation between individuals. Glucosiduronate fractions comprised the dominant excreted radioactivity. In vitro incubation of normal human liver also produced five conjugate types. Simultaneous intravenous/oral ( 14C/ 3H) administration of EE 2 demonstrated conversion to identical urinary conjugate and free steroid products, with a greater excretion of the intravenous material. Authentic 3-glucuronide of EE 2 was synthesized and its position in the chromatographic system relative to the urinary conjugate peaks demonstrated.
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