Abstract
Human Umbilical Cord-Derived Mesenchymal Stem Cells as a Source of Odontoblasts: a GMP-compliant approach
Highlights
The treatment protocol of penetrating caries involves root canal treatment, which removes the inflamed tissue and nociceptive nerve endings, ensures pain sedation and prevents outbreaks of infection with undesirable outcomes on the overall health
Umbilical cord-derived mesenchymal stem cells (UC-Mesenchymal stem cells (MSCs)) are considered to be adult stem cells that can be obtained in large numbers
The literature reports the existence of at least three distinct populations of stem cells belonging to the MSC family [4] derivable from dental tissues: stem cells from human exfoliated deciduous teeth (SHEDs) [5], postnatal human dental pulp stem cells (DPSC) [6] and periodontal ligament stem cells PDLSC [7]
Summary
The treatment protocol of penetrating caries involves root canal treatment, which removes the inflamed tissue and nociceptive nerve endings, ensures pain sedation and prevents outbreaks of infection with undesirable outcomes on the overall health. UC-MSCs exhibit strong proliferative ability, low immunogenicity, and multi-potential differentiation, all of which contribute to the success of cell transplantation [11] Due to their stem cells features, SHEDs and UC-MSCs rapresent an interesting model to study odontoblast differentiation and UC-MSC the best source of stem cell to perform the transplantation. Using SHEDs and UC-MSCs, as a starting material, by means of using stem cells manipulated ad hoc for treating penetrating caries, we were able to improve the possibility of inducing differentiation towards odontoblasts with a clinical protocol in compliance with GMP, avoiding animal reagents, and including the use of platelet lysate (PL) and molecules of human origin. We suggest a possible step forward in identifying the conditions for reducing costs for the clinical production of cells
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