Abstract
Expression of estrogen receptor β in hypothalamic stem cells
Highlights
Developmental estrogen treatment enlarges the sexually dimorphic nucleus of the preoptic area (SDNPOA) in male and female weanling rats [1]
Serving as the within-subject negative control, there was little estrogen receptor β (ERβ)-ir labeling in the 3rd ventricle cavity, where no tissue existed
The novel findings in the present study include the demonstration of ERβ immunoreactivity in the 3rd ventricle stem cell niche (3VSCN), in both nestin- and Ki67-positive cells
Summary
Developmental estrogen treatment enlarges the sexually dimorphic nucleus of the preoptic area (SDNPOA) in male and female weanling rats [1]. Neural stem cell activity at least partially accounts for postweaning SDN-POA development [2, 3]. The 3VSCN appears distinguishable from other sections of the 3rd ventricle [2], such as the caudal portion, by its vigorous expression of nestin, a stem cell biomarker [5,6]. Estrogen selectively mobilizes neural stem cells in the 3VSCN of postnatal day (PND) 21 rats, as evidenced by an increase in proliferative cell number and an increase in mitotic activity [7]. It remains unclear as to whether estrogen controls the differentiation of stem cells (stem cellàneuronspecific progenitor cellàCB28-expressing neurons) by which the size of the SDN-POA is determined [1,2]
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