Human Serum Protein-Bound iodine and Protein Fractions at Different Physiological and Narcotic States

Abstract

Iodine profile of Nigerians at different ages in both sexes and in pregnant women, and under narcotic influence, such as alcoholism, cigarette smoking and marijuana addiction were studied. Their serum total protein, albumin and globulin concentrations were also determined. Results of the study showed that serum protein bound iodine levels increased significantly with age in both sexes and in pregnant women, while it decreased significantly in alcoholics, cigarette smokers and marijuana addicts. Serum total protein, albumin and globulin levels increased with age in both sexes and in pregnant women, but were decreased significantly in alcoholics, cigarette smokers and marijuana addicts. Data of the study indicate that serum protein bound iodine levels were potentiated by age, sex and pregnancy, but were impaired by alcoholism, cigarette smoking and marijuana addiction. In addition, serum total protein, albumin and globulin levels were affected by age, sex, pregnancy, cigarette smoking and marijuana addiction. Alcoholism, cigarette smoking and marijuana addiction may have deleterious effects on thyroid function and protein synthesis. NQJHM Vol. 14 (3&4) 2004: pp. 257-261