Abstract
The secretory responses of several proteins in parotid secretions were examined by measuring concentrations before, during and after 80 min of gustatory stimulation. The average secretion rate (μg/min/gland) of amylase increased upon stimulation about 16 times, that of lactoferrin and free secretory piece about 5 times, and that of IgA about 2.5 times. Thus, IgA is not transmitted by the gland like the typical secretion-specific proteins. Glandular transfer of IgA and IgM appeared comparable, and may be characterized as facilitated diffusion which is highly selective when compared with the passive external transmission of IgG and albumin. When levels of individual salivary proteins are studied, differences in the influence of flow rates must be appreciated. Expressions such as mg/100 mg of total protein should be avoided. Adverse effects of sample storage have to be considered, particularly for levels of IgA and amylase in unstimulated secretions.
Published Version
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