Abstract
Summary Serotonin and histamine putatively affect the onset of some diarrheic syndromes. We have studied the effects of human rotavirus infection on histamine and serotonin release from human intestinal carcinoide cell culture. The viral infection triggered a seven-fold increase in serotonin concentration and a two-fold increase in histamine concentration in culture supernatants. These results suggest that serotonin production is implicated in the pathophysiology of rotavirus-induced diarrhea.
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