Abstract
Inositol hexakisphosphate (InsP 6 ), also known as phytic acid, is a potent chelator of bivalent cations. Intracellular InsP 6 molecules are associated with magnesium. Calcium is the prevalent bivalent cation outside the cell and its association with InsP 6 could lead to the formation of insoluble complexes. To avoid the formation of dangerous InsP 6 /Calcium precipitates in the bloodstream, mammals must possess a robust InsP 6 phosphatase in their plasma. Here we identify the Multiple Inositol Polyphosphate Phosphatase 1 ( MINPP1 ) as the InsP 6 phosphatase present in human plasma.
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