Human Papillomavirus (HPV) in Oral Cavity Lesions: Comparison with Other Oral Cancer Risk Factors

Abstract

Hu man papillo mavirus (HPV) is considered a necessary factor for the development of cervical cancer; however, its relat ionship with oral cancer is controversial. The aim of this study was detect the presence of HPV in lesions of the oral cavity and its correlation with other risk factors. Presence of HPV was studied by polymerase chain reaction in samples fro m benign lesions, potentially malignant lesions (PML), neoplasias and healthy mucosae. The results from the different groups were co mpared; in addition to their histopathological variab les with tobacco smoking, alcohol consumption, so on. HPV was detected in 88.89% of benign lesions, 41.38% of PM L and 56.25% of neoplasias. The most prevalent genotypes were 16 and 6. Together, reached 55% of the total number of cases. A significant association was observed between HPV and male gender, tobacco smokers, alcohol drin kers and benign lesions. Tobacco smoking and alcohol intake were associated to neoplasias. Our results showed that factors like tobacco smoking and alcohol drinking, have more influence than HPV in the development o f oral neoplasias; however, 56.2% of the neoplasias tested positive for HPV; the percentage of HR-HPV detection increased with the severity of the lesions, suggesting its possible involvement in malignant processes