Abstract
Psoriasis a common autoimmune disorder characterized by T cell mediated keratinocyte hyperproliferation known to be associated with the presence of certain specific HLA alleles. In this study our aim was to evaluate distribution of Human leukocyte antigen (HLA-Cw) susceptible allele of psoriasis from patients in Western India. The study included 84 Psoriasis patients and 91 normal individuals from the same geographical region. Human leukocyte antigen HLA-C was typed using high resolution polymerase chain reaction- sequence specific oligonucleotide probes (PCR-SSOP) technique. The study revealed significant increase in frequencies of Cw*0202 (OR-6.508, P<0.0001) and Cw*0604 (OR-17.710, P=0.0153) when compared to controls while Cw*1502 (OR-0.130, P=0.0490) were significantly decreased in psoriasis patients. Our study shows a strong association of HLA Cw*0202 and Cw*0604 alleles with psoriasis conferring to its susceptibility to psoriasis patients from Western India. Key words: HLA Cw alleles, Psoriasis, Mumbai, Western India
Paper version not known (
Free)
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Medicine and Medical Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
