Abstract
Acute leukemias are characterized by the elonogenic proliferation
 
 of haemopoietic progenitor cells arrested in maturation. Clinical
 manifestations are related to the infiltration of the bone marrow and other
 tissues by the leukemic blasts.
 
 Peripheral blood mononuclear cell (PBMC) from luekemic patients
 (29)ANLL,(36)ALL and from normal donors(55)were typed for HLA-
 DP specificities using microlymphocytotoxicity assay.
 
 Results showed frequencies of DPw alleles in ANLL patients were
 not significantly different from controls ,exept that in DPw1 was absent
 .In contrast ,in ALL,frequencies of DPw2 and DPw5 were significantly
 increased (p<0.05, relative risk (RR) = 1.95 and p<0.01, RR=4.27,
 respectively.
 
 These results ,therefore ,demonstrate both positive negative
 associations between major histocompatibility complex (MHC) gene
 products which are in only very weak linkage with the rest of HLA ,and
 ALL,ANLL patients.The HLD-DP region could thus contain long sought
 – after genes influencing susceptibility and resistance to leukeemogenesis.
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