Abstract
WE have described genetic polymorphism of the fourth component of human complement (C4) and postulated that it was determined by an autosomal locus close to HLA-B on chromosome 6 (refs 1,2). From familial and population studies of the electrophoretic C4 patterns, O'Neill et al.3 postulated that there are two C4 loci in all individuals, and that C4° alleles occur with high frequency at both. It was further shown that the blood groups Chido (Ch) and Rodgers (Rg) are closely associated with certain C4 types and indeed represent antigenic determinants on C4 molecules4, probably on the C4d part5. In this report we have used immunochemical methods to show that the C4 locus is definitively duplicated at least on some chromosomes. The implications are that the locus is either duplicated on all chromosomes and C4° alleles occur frequently at both, or alternatively, that the locus is duplicated on some chromosomes only.
Published Version
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