Human and Animal Brucellosis in Nigeria: A Systemic Review and Meta-Analysis in the Last Twenty-One Years (2001-2021).

Abstract

Simple SummaryBrucellosis caused by Brucella spp. is transmitted by direct or indirect contact with infected animals or their secretions and through the consumption of infected animal meat and unpasteurized milk/milk products. Brucellosis is classified as one of the top neglected zoonosis by the World Health Organization (WHO), and despite this, it does not attract the appropriate attention it requires from both the Federal and State ministries of health in Nigeria. Currently, there is a lack of coordinated national data on the prevalence and distribution of human and animal brucellosis. Thus, published research works between 2001 and 2021 were studied based on set criteria to estimate the burden and distribution of brucellosis in Nigeria. The results of the national seroprevalence of human and animal brucellosis were 17.6% (554/3144) and 13.3% (8547/64,435), respectively. Specifically, 15.8% (7178/45,363) seroprevalence of brucellosis was recorded in northern Nigeria as against 8.7% (1902/21,740) in the southern part. Brucella abortus, B. melitensis, B. suis, and B. canis were reported in 27 of the 36 states. Improved sanitation at the abattoirs, use of personal protective equipment by animal handlers, vaccination of animals against brucellosis, and ranching of animals to curb the spread of the disease should be paramount to all stakeholders.The global burden of human and animal brucellosis remains enormous. The disease, which is endemic in Nigeria, lacks appropriate attention and national data. This review estimated the burden and distribution of human and animal brucellosis in Nigeria in the last twenty-one years (2001–2021). Publications reporting the detection of brucellosis in Nigeria were sorted from different search engines, including PubMed, ResearchGate, Scopus, and Google Scholar, to generate data on its prevalence, spatial distribution, and predisposing factors. The results of the national seroprevalence of human and animal brucellosis as revealed in this study were 17.6% (554/3144) and 13.3% (8547/64,435), respectively. Specifically, 15.8% (7178/45,363) seroprevalence of brucellosis was recorded in northern Nigeria as against 8.7% (1902/21,740) seroprevalence in the southern part. It also indicated that 78.7% of the detected brucellae were un-typed. The Brucella species detected were B. abortus (15.2%), B. melitensis (4%), B. suis (1.8%), and B. canis (0.4%). This study revealed that brucellosis is endemic in Nigeria. Culture and molecular methods for detecting brucellosis and reports on antimicrobial susceptibility testing remain a conjecture. This review will help researchers redirect their research focus and serve as a guide for policymakers on measures for managing brucellosis in Nigeria.