Abstract
Human adenoviruses (HAdVs) type 7 can cause severe respiratory disease. During the period between December 2018 and August 2019, HAdV-7 infection was identified in 129 patients in Wuhan Children’s Hospital, Hubei Province, China. Samples were collected from hospitalized children and metagenomic sequencing was applied to detect the HAdV infections. Hemophagocytic lymphohistiocystosis (HLH) related to HAdV infections was observed in some patients clinically and patients were divided into two groups based on this to test the differences among clinical indicators. Genome variation, in silico restriction endonuclease analysis (REA), and phylogenetic analyses were carried out to show the genome characterization of HAdV-7 in this study. It was found that many indicators, such as all blood routine indicators, in patients of the HLH group showed significant levels. In this study, REA revealed that HAdV-7 might belong to genome 7d and genome variation analysis displayed the stable genome of HAdV. HAdV-7 is an ongoing threat to the public, and global surveillance should be established.
Highlights
Human adenoviruses (HAdVs) are one of the most common pathogens responsible for respiratory infections
HAdV infection was detected in 129 children with severe respiratory symptoms from December 2018 to August 2019 in Wuhan Children’s Hospital, and the number of patients reached a peak in May 2019 (Figure 1A and Supplementary Table 1)
This study describes a regional outbreak of HAdV-7, of which the genome type was 7d, among children younger than eight years in Hubei Province, China between December 2018 and August 2019
Summary
Human adenoviruses (HAdVs) are one of the most common pathogens responsible for respiratory infections. The origin of HAdV-7d was recognized as China, where it circulated from 1958 to 1990 and replaced genome type HAdV-7b as the predominant epidemic strain (Wadell et al, 1985; Li et al, 1996; Zhao et al, 2014). After this it vanished for almost twenty years, and HAdV7d re-emerged in China in 2009 and caused an outbreak in Guangdong Province in 2011 (Zhao et al, 2014)
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