Abstract
This study is aimed to explore the efficiency of [hydroxy(tosyloxy)iodo]benzene (HTIB) in the oxidative cleavage of some pyrimidinyl hydrazones. The protocol involves stirring the hydrazone derivatives with HTIB in dichloromethane at room temperature. The oxidative cleavage of C = N in pyrimidinyl hydrazones regenerated parent ketones in high yields. The methodology has advantage of preventing over oxidation of carbonyl functionality.. KEYWORDS :[Hydroxy(tosyloxy)iodo]benzene, Hydrazone, Hypervalent iodine reagent, Oxidative cleavage, Pyrimidine.
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