Abstract
Behçet’s disease (BD) affects multiple organs. It is mainly characterized by recurrent oral, skin, and genital aphthous ulcers, and eye involvement. Successful management of BD is increasing, although its etiology remains unclear. A number of etiologies have been proposed, including environmental, genetic, viral, and immunological factors. To understand its complex etiology and improve its management, animal models of BD have been used to enable more effective therapeutic applications with increased clinical significance. An herpes simplex virus (HSV) type 1-induced BD mouse model has shown disease characteristics similar to those seen in BD patients. An HSV-induced BD animal model has been used to test various therapeutic modalities. The applied modalities are several materials that are derived from natural products, conventional therapeutics, and possible biologics. In this review, we provided how they regulate inflammation in an HSV-induced BD model.
Highlights
Behçet’s disease (BD) is a chronic, relapsing, multi-systemic, and vascular inflammatory disorder that affects many organ systems, including mucocutaneous, ocular, vascular, arthritic, gastrointestinal, and central nervous systems [1]
Herpes simplex virus (HSV) ribonucleotide reductase 1 mRNA was not detected in skin lesions of mice through polymerase chain reaction (PCR), even this lesion was induced by HSV inoculation [1]
These findings suggest that Polycytidylic Acid (Poly I):C might have therapeutic application in
Summary
Behçet’s disease (BD) is a chronic, relapsing, multi-systemic, and vascular inflammatory disorder that affects many organ systems, including mucocutaneous, ocular, vascular, arthritic, gastrointestinal, and central nervous systems [1]. Several factors, including environmental pollutants, infections, genetic polymorphism, and immune dysregulation, have been suggested as factors affecting the pathogenesis of BD. It seems likely all these factors may contribute together [2]. HSV-induced BD animal models have been shown to have similar inflammatory responses compared with BD patients, such as mucocutaneous, ocular, vascular, arthritic, and gastrointestinal involvement [7]. Using HSV-induced inflammatory BD animal models, therapeutic effects of natural products, and new biological agents have been applied in recent years.
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call