Abstract
Levonorgestrel, 13β-ethyl-17β-hydroxy-18,19-dinor-17α-pregn4-en-20-yn-3-one (Figure 1), is a safe, potent, synthetic steroidal hormone that is widely used in several contraceptive delivery systems [1, 2], for example oral contraceptives and injectable [3], implantable [4, 5], and intrauterine devices [6]. Evolution of an existing drug molecule from a conventional form to a polymeric novel delivery system can significantly improve its performance in terms of patient compliance, safety, and efficacy. Among these polymeric systems, biodegradable in-situ-forming drug-delivery systems have received considerable attention over the past few years [7–9]. Dunn et al. [10] introduced an in-vivo setting system, made from biodegradable polymers, for human and veterinary purposes. This injectable implant system comprises a water-insoluble biodegradable polymer, for example poly (DL-lactide-co-glycolide), dissolved in a water-miscible, physiologically compatible organic solvent, for example N-methyl-2-pyrrolidone. On injection into an aqueous environment, the organic solvent diffuses into the surrounding environment while water diffuses into the polymer matrix. The polymer precipitates on contact with the water and results in a solid polymeric implant.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call