HPR21 Implementation Challenges and Real-World Impacts of Switching Pediatric Vaccines: A Global Systematic Literature Review

Abstract

Switching a vaccine for another on a pediatric national immunization program is often done for the betterment of society. Poorly implemented switches may introduce challenges, such as unaccounted for resource use consumed during the transitions or suboptimal transitions, negatively affecting vaccine access or producing unwanted health system impacts. Therefore, this systematic review aimed to evaluate the global evidence indexed in electronic databases on implementation challenges of pediatric vaccine switches and the real-world impact of those challenges.