Abstract
The preparation and the structural characterization of a p‐tert‐butyl‐calix[8]arene‐bonded silica gel stationary phase (CABS) have been reported. Subsequently, in this paper, the investigation of its HPLC performance was carried out using neutral, basic, and acidic solutes as probes. Meanwhile, the compared study with conventional ODS also was done under the same conditions. The results show that CABS can behave a reversed‐phase material with weaker hydrophobicity relative to ODS. Additionally, hydrogen bonding, π‐π and inclusion interaction between CABS and polar analytes, such as N‐substituted anilines, phenols, and so on, can also be observed. The versatile performance should be related to the calix[8]arene ligand, which can provide different sites for solutes. An advantage of CABS over ODS lies in its high selectivities for polar aromatics and the fast separation of nonpolar hydrocarbons.
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