Abstract
In the present work antihyperglycemic screening of the polyherbal powder was carried out by oral administration of an aqueous extract of polyherbal powder on alloxan-induced diabetic rats. The polyherbal powder displayed a substantial increase in hypoglycemic efficacy at a dose of 100 mg/kg and 200 mg/kg in both Alloxan-induced diabetic rats and normal rats. The powder also exhibited enhancement in various parameters like the glycogen content of the liver, restoration of pancreatic β-cells, body weight, and carbohydrate metabolizing enzymes. Results obtained showed that the Alloxan diabetic rats on treatment with polyherbal powder at various doses of 100 mg/kg and 200 mg/kg considerably improved their body weights to 222.30 ± 3.42 g and 221.6 ± 3.60 g when compared to non-diabetic rats respectively. In addition to this, the histopathological analysis demonstrated that polyherbal powder enhanced the histological architecture of the islets of Langerhans significantly which is on par when compared to the standard Glibenclamide
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