Abstract
HPLC and Densitometric TLC Methods for Simultaneous Determination of Pazufloxacin with Some Co-Administered Drugs in Human Plasma
Highlights
Pazufloxacin(-)-(S)-10-(1-aminocyclopropyl)-9-fluoro-3methyl-7-oxo-2,3-dihydro-7Hpyrido[2,3-de][1,4]benzoxazine-6carboxylicacid monomethanesulfonate is a fluoroquinolone synthesized by Toyama Chemical Co
The literature survey revealed that analytical methods reported for the estimation of pazufloxacin mesylate in human plasma include chemiluminescence flow injection [4] and HPLC methods [5,6,7]
No method has been reported for determination of pazufloxacin mesylate in human plasma with co-administered drugs by HPLC and densitometric TLC
Summary
Pazufloxacin(-)-(S)-10-(1-aminocyclopropyl)-9-fluoro-3methyl-7-oxo-2,3-dihydro-7Hpyrido[2,3-de][1,4]benzoxazine-6carboxylicacid monomethanesulfonate is a fluoroquinolone synthesized by Toyama Chemical Co. No method has been reported for determination of pazufloxacin mesylate in human plasma with co-administered drugs by HPLC and densitometric TLC. It was reported that the antibacterial activity of pazufloxacin mesylate was enhanced significantly in presence of cefoperazone and sulbactam sodium. Their antibacterial action in vitro was characterized by synergism and additive action instead of antagonistic effect [8,9]. The proposed research work describes the estimation of pazufloxacin mesylate with cefoperazone and sulbactam sodium in human plasma by RP-HPLC and TLC using moxifloxacin as an internal standards (Figure 1)
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