Abstract
Mast cells (MCs) are an integral part of the immune system. They play a pivotal role in several allergic and other immune responses. MCs store several mediators in their granules and synthesize new mediators which facilitate their function. The levels of some of those mediators and/or their metabolites are used for the diagnosis of MC activation and MC disorders. 1 Weiler CR Austen KF Akin C et al. AAAAI Mast Cell Disorders Committee Work group report: mast cell activation syndrome (MCAS) diagnosis and management. J Allergy Clin Immunol. 2019; 144: 883-896 Abstract Full Text Full Text PDF PubMed Scopus (37) Google Scholar Nevertheless, recent data regarding some of those mediators need to be addressed and incorporated into the diagnostic criteria of MC activation and disorders. 2 Luskin KT White AA Lyons JJ The genetic basis and clinical impact of hereditary alpha-tryptasemia. J Allergy Clin Immunol Pract. 2021; 9: 2235-2242 Abstract Full Text Full Text PDF PubMed Scopus (13) Google Scholar ,3 Lyons JJ Chovanec J O'Connell MP et al. Heritable risk for severe anaphylaxis associated with increased α-tryptase-encoding germline copy number at TPSAB1. J Allergy Clin Immunol. 2021; 147: 622-632 Abstract Full Text Full Text PDF PubMed Scopus (62) Google Scholar
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