How does the method of formulation a drug affect its efficacy and safety, based on the comparison of modified and conventional release amantadine in the treatment of levodopa induced dyskinesia in patients with Parkinson's disease?

Abstract

Background The choice of the appropriate method of drug production is determined mainly by the characteristics of the medicinal substances and excipients, the type of disease in which the drug is to be used and the expectations of patients. The appropriate method of drug production may be key importance for achieving clinically significant treatment effects. For this reason, an attempt has been made to evaluate modified and conventional release forms of amantadine for the treatment of levodopa-induced dyskinesias in patients with Parkinosn's disease. Methods The effect of two different forms of amantadine on the treatment of levodopa - induced dyskinesias in patients with Parkinson's disease was assessed through a systematic review of clinical trials following the PICOS regimen. The clinical efficacy of the treatment of levodopa-induced dyskinesias in patients with Parkinson's disease was assessed by a measure of the appropriate scale and the effect on the ON and OFF times. Results Although no studies were found directly comparing the use of amantadine ER with amantadine IR in this disease, in the studies of amantadine ER, the UDysRS score showed a significantly greater improvement in the treatment of dyskinesia in the study group compared to placebo. The amantadine IR studies did not show any significant effect on the treatment effects. Conclusions The choice of the method of producing a drug has a significant impact on the effects of treatment.