Abstract
Mammalian dorsal root ganglia (DRG) contain a diverse collection of sensory neuronal subtypes specialized to detect different sensory stimuli. Most of these cells respond to mechanical stimulation of some sort, be they proprioceptors detecting body movements, receptors for gentle touch or nociceptors activated by painful levels of pressure, and yet the proteins that detect mechanical stimuli remain unknown. In this issue of The EMBO Journal, Gary Lewin and colleagues give insights into the developmental acquisition of mechanosensitivity by different classes of sensory neurons and in doing so, they offer a new approach for determining the molecular basis of this sensory modality.
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