Abstract
Lipoxygenases (LOXs) are lipid-peroxidizing enzymes that are classified with respect to their positional specificity of arachidonic acid oxygenation. This classification is rather descriptive and its structural basis is not well understood. In the absence of direct structural data on enzyme/substrate interaction, a combined strategy of fatty acid modification, site-directed mutagenesis and modeling was employed to investigate the structural basis of LOX specificity. In this paper, the recent advances in structural biology of LOXs are reviewed with particular emphasis on the sequence determinants of the positional specificity of mammalian LOXs.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.