Abstract
Lipoxygenases (LOXs) are lipid-peroxidizing enzymes that are classified with respect to their positional specificity of arachidonic acid oxygenation. This classification is rather descriptive and its structural basis is not well understood. In the absence of direct structural data on enzyme/substrate interaction, a combined strategy of fatty acid modification, site-directed mutagenesis and modeling was employed to investigate the structural basis of LOX specificity. In this paper, the recent advances in structural biology of LOXs are reviewed with particular emphasis on the sequence determinants of the positional specificity of mammalian LOXs.
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