Abstract
Lacking eyes to see and ears to hear, cells physically sense their microenvironment and feel into the depths of a matrix by actively deforming their surroundings. To study how deeply cells feel, mesenchymal stem cells, as prototypical but particularly sensitive adhesive cells, were cultured on collagen-coated gels-based microfilms of controlled elasticity (E) and thickness (h). Cellular morphologies and nuclear deformations were distinctively smaller on soft compared with soft but thin or stiff films.
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