Abstract
Introduction: Household air pollution (HAP) from incomplete combustion of solid fuels is responsible for =4 million deaths annually, mostly due to cardiopulmonary disease. Limited data describe the associations between HAP and echocardiographic markers of cardiac structure and function. Thus, we assessed the cross-sectional association of median 24hour home indoor measures of fine particulate matter (PM2.5) and carbon monoxide (CO) with echocardiographic characteristics among women. Methods: We analyzed baseline data of 44 women (mean age: 34.5 years, SD: 6.4) enrolled in a prospective cookstove replacement study in a rural Kenyan community. Home echocardiographic assessment included chamber size, ventricular function, hemodynamics, and myocardial strain. Linear regression models were used to estimate the crosssectional association between tertiles of HAP measures and continuous echocardiographic outcomes, while adjusting for age, body mass index, and level of education. Results: All women used wood as cooking fuel. CO levels ranged from 3 to 89 ppm while PM2.5 levels ranged from 7 to 1475 µg/m3. CO was associated with higher pulmonary artery diastolic pressure (2.8 mmHg (95% CI: 0.1, 5.4) for tertile 3 vs 1; Ptrend=0.047) and lower left ventricular ejection fraction ( -6.2% (95% CI: -9.9, -2.5) for tertile 3 vs 1; Ptrend
Published Version
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