Hot-melt extrusion technique: A novel continuous manufacturing method for enteric-coated pellets

Roychowdhury Rajeshwari,Rathnanand Mahalaxmi,Kara Divya Dhatri

doi:10.7324/japs.2021.110702

Abstract

The technology of hot-melt extrusion (HME) is becoming a progressively appealing way to develop different drug delivery systems. A wide range of pharmaceutical dosage forms and formulations from oral to topical and parenteral can be prepared. The dosage forms formulated using HME technique are composite mixtures of active pharmaceutical agents, active excipients, and other processing aids. HME has many advantages over traditional techniques of pharmaceutical development, such as non-solvent technology, lower processing requirements, uninterrupted activity, and greater possibility of uniform suspension and increased bioavailability. This paper addresses enteric-coated pellet pharmaceutical applications and its process techniques using the HME technology and its applications in pharmaceutical industries for an efficient pathway for a novel drug delivery system.

Highlights

Over the past years, many kinds of dosage forms have been discovered, but the problem of solubility is still a major issue
This paper addresses enteric-coated pellet pharmaceutical applications and its process techniques using the hot-melt extrusion (HME) technology and its applications in pharmaceutical industries for an efficient pathway for a novel drug delivery system
One of the techniques that has emerged as a promising method for developing enteric-coated pellets and other dosage forms is hot-melt extrusion (HME)

Summary

Introduction

Many kinds of dosage forms have been discovered, but the problem of solubility is still a major issue. This paper addresses enteric-coated pellet pharmaceutical applications and its process techniques using the HME technology and its applications in pharmaceutical industries for an efficient pathway for a novel drug delivery system. One of the techniques that has emerged as a promising method for developing enteric-coated pellets and other dosage forms is hot-melt extrusion (HME).

Results

Conclusion