Abstract
The use of hot-melt extrusion (HME) within the pharmaceutical industry is steadily increasing, due to proven its ability to efficiently manufacture novel products. With the use of HME we can increase solubility and bioavailability of the API. HME has proven to be a robust method of producing numerous drug delivery systems like modified, controlled and targeted drug delivery systems. resulting improved bioavailability as well as taste masking of bitter active pharmaceutical ingredients (APIs). Hot-melt extrusion techniques are pragmatic in the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, suppositories, implants, stents, transdermal systems and ophthalmic inserts. In This paper we review about the types of Extruder, solid dispersion and Application of the HME to the pharmaceutical industries.
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