Abstract
Background: Intracranial trauma (IT) is an injury inside of the cranial box resulting from external forces, usually caused by automotive accidents, falls and violence, sometimes leading to permanent damage or death. Objectives: Describe hospital admissions for IT in the metropolitan region of São Paulo (SP), based on ICD-10 morbidity list. Design and settings: Epidemiological, descriptive and retrospective study. Methods: Data provided from the Hospital Morbidity System (SIH-SUS) of the Ministry of Health, from January 2015 to December 2020. Results: There were 65.455 cases of hospitalizations by IT registered in the metropolitan region of SP, which surpassed the cases of the North and Midwest regions. In 2020, there was a 5% reduction in cases compared to 2019. The amount spent represented 10.5% of the total spent in Brazil. Most of the hospitalization patients were male, and the most affected age group was 40- 49 years. The lethality was 11.05% and higher in patients over 80 years-old. Conclusions: It is essential to control IT’s causing factors, since it engenders high costs, and it is a serious problem for the public health and economy, and for the victim’s psychosocial context. The metropolitan region of SP requires special attention, once it shows higher rates of hospitalizations, morbidity, and mortality than any other brazilian state. Despite the social isolation in 2020, there were no significant differences between this year’s records comparing to the other ones.
Highlights
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
Objectives: The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
The analyses showed significantly higher frequency of the genotype VV in those who had depression, compared with the allele A
Summary
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Neuroinfections are pathologies that affect the CNS, for example, we have Murcomycosis, a progressive infection caused by opportunistic fungi of the order Mucorales, with high frequency in Immunodepressed patients, Diabetes Mellitus (DM) is the main underlying pathology associated with the development of Rhinocerebral Murcomycosis, which represents 50% of the cases, with a mortality rate of 70% (Sidrim, 2012, p.168). The COVID-19 pandemic has been alarming the world since its first outbreak in December 2019 In this scenario, the presence of aggravating factors such as the elevation of the D-dimer and the reduction of the angiotensin-converting enzyme 2 (ACE2) during the clinical course of the disease, collaborated in the appearance of thromboembolic events derived from inflammatory processes and extensive intravascular coagulation, contributing to the emergence of diseases such as Hemorrhagic Stroke (ICH), leading the patient to have a worse clinical prognosis and a consecutive worsening of their health. Despite being classically associated with this etiology, the finding may be present in other diseases, especially infiltrative ones
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