Abstract
DNA-dependent RNA polymerase was found not only in chromatin fraction but also in nucleolar fraction of normal rat liver cells as well as rat ascites hepatoma cells. Nucleolar RNA polymerase was more sensitive to the administration of steroid hormone than chromatin RNA polymerase. In hepatoma cells, chromatin RNA polymerase was rather insensitive to the steroid hormone. The analytical results of in vitro synthesized RNA by nucleolar RNA polymerase did not show ribosomal precursor but only 6S RNA.
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