HORMONAL CHANGES ASSOCIATED WITH PELVIC ORGAN PROLAPSE

Abstract

Goal. To determine the characteristics of the level of sex hormones in the blood plasma in women with genital prolapse urinary incontinence. Material and methods. The study was conducted on the basis of the Surgical Training Building of the Azerbaijan Medical University from December 2017 to May 2021. Questionnaires for socio-demographic/clinical data PFDI-20 and PFIQ-7 to detect genital prolapse and urinary incontinence were applied to 144 patients of reproductive age. All patients were divided into three groups: I a - main group, prospective analysis of 50 women aged 25 to 50 years with prolapse of the anterior vaginal wall and urinary incontinence; I b is the main group, which will include women with relapses after surgical interventions for this pathology in the amount of 59 (retrospective material); II - comparative group: practically healthy women without genital prolapse and urinary incontinence, who had a history of 3 or more births (35 women). A hormonal background study was conducted in 50 women with signs of PG (the main group) aged 25 to 50 years (average age -39.7 ± 7.3 years). The levels of testosterone, estradiol, progesterone, Anti-Muller hormone and cortisol in the blood serum were determined. Determination of the level of hormones in blood plasma was carried out on the immunoanalyzer Miсroplate reader RD-2100C (PRC). Results. It was found that the level of estradiol in the examined women varied between 31.1 – 84.6 nmol/L. In 13 patients of the main Ia group, the level of estradiol varied from 31.3 to 44.8 nmol/L. In 14 patients, estradiol was in the range of 47.3 – 53.8 nmol/L, in 16 patients the estradiol level varied between 57.6 – 64.6 nmol/L, in 4 patients the estradiol index was in the range of 65.8 – 71.0 nmol/L and in 3 patients in the range of 76.3 – 84.6 nmol/L. Conclusions. The average levels of estradiol, progesterone and testosterone in patients of reproductive age with genital prolapse and urinary incontinence did not differ significantly. The Anti-Muller hormone index differs in patients with genital prolapse and urinary incontinence from compared with the control (U =613.0, p≤0.001). The quantitative value of Anti-Muller hormone is significantly reduced and is within the range that is typical for women during menopause. The cortisol index is statistically significantly different in patients with genital prolapse and urinary incontinence from healthy women.(U =690,0, p≤0,001)