Homologous tumor cell membrane vesicles active preferential self-recognition of tumor cells in vitro

Chenghu Wu,Ailin Yu,Mingbo Fan,Yue Chen

doi:10.1186/s13765-022-00672-3

Abstract

Cell membrane vesicles, as delivery carriers of drugs or biological agents in vivo, are an important therapeutic mode in the study of disease treatment. Tumor membrane-derived vesicles have been widely used in tumor therapy because of their good tumor enrichment effect. The most common method is the surface of nanoparticles coated with tumor cell membrane, which can effectively prolong the circulation time of particles in the blood and the enrichment of tumors. In this study, we prepared vesicles of different tumor cell membrane derivate and studied their targeting to tumors detailly. The results showed that homologous vesicles have high targeting to homologous tumor cells. The fluorescence of vesicles in homologous tumor cells was significantly higher than that in other tumor cells. This study will provide a new strategy and guidance for the clinical treatment of cancer based on the tumor cell membrane system.Graphical

Highlights

Tumor is still a huge killer that seriously affects public life and health, and there is still a lack of effective treatment at present [1]
We carefully investigated the tumor-targeting of cell membrane vesicles of different tumor cell origins at the cell level in vitro
Flow cytometry results showed that homologous tumor cells had the highest uptake efficiency of tumor cell membrane vesicles

Summary

Introduction

Tumor is still a huge killer that seriously affects public life and health, and there is still a lack of effective treatment at present [1]. More and more researchers have found that many cell membranes have very different biological functions, which can be used to solve the difficulties in current research or application. There are many applications of such research, and many good results reveal the advantages of these cell membrane treatment system.

Results

Conclusion