Abstract
HomoKinase database is a comprehensive collection of curated human protein kinases and their relevant biological information. The entries in the database are curated by three criteria: HGNC approval, gene ontology-based biological process (protein phosphorylation), and molecular function (ATP binding and kinase activity). For a given query protein kinase name, the database provides its official symbol, full name, other known aliases, amino acid sequences, functional domain, gene ontology, pathways assignments, and drug compounds. In addition, as a search tool, it enables the retrieval of similar protein kinases with specific family, subfamily, group, and domain combinations and tabulates the information. The present version contains 498 curated human protein kinases and links to other popular databases.
Highlights
In human genome, the protein kinase is one of the largest recognized protein families which regulate multiple biological processes by posttranslational phosphorylation of serine, threonine, and tyrosine residues [1]
We developed curated human protein kinases database known as “HomoKinase.” First, each entry in the database was checked with HUGO Gene Nomenclature Committee (HGNC) to confirm whether it is approved or not
The conserved protein kinase core consists of two lobes: a smaller Nterminal lobe (N-lobe) with ATP binding site and a larger C-terminal lobe (C-lobe) with catalytic site responsible for kinase activity [3, 10]
Summary
The protein kinase is one of the largest recognized protein families which regulate multiple biological processes by posttranslational phosphorylation of serine, threonine, and tyrosine residues [1]. Human genome contains 500 protein kinase genes that constitute about 2% of all genes [2]. 2000 protein kinases are encoded by human genome. 30% to 50% of proteins may undergo phosphorylation; improper functioning of kinase may lead to various human diseases [4]. Protein kinases are involved in regulation of many processes, so they are linked to many diseases and act as target for drug design. Protein kinases are the group of enzymes that share conserved catalytic domains involved in stimulating catalytic activity of enzymes and act as ATP binding sites. This result the need and availability of databases specific to protein kinases
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