Homoimmune Uveitis in the Guinea Pig

Abstract

Introduction As noted in Sections II 1 and III, 2 of this series, experimental homoimmune uveitis primarily affected part or all of the uveal tract. Secondary involvement occurred in the vitreous, retina, and limbus. The possibility of spontaneous uveitis as well as adjuvantinduced uveitis had to be considered. It also was necessary to identify injuries and intercurrent ocular disease in the guinea pig and evaluate their relationship with clinical and histologic homoimmune uveitis. Materials Donor Eyes. —Some of the pigmented and albino eyes which were used for the preparation of pigmented and albino uveal antigens, comprising approximately 5,000 eyes, were studied grossly for eye disease. Normal Eyes (Nonexperimental). —Selected animals were chosen from the donor guinea pig group as well as from nonexperimental adult and newborn animals. This group composed approximately 60 eyes. Adjuvant Control Eyes. —The 250 eyes of control animals in Experiments I, II, III, IV made up