Abstract
The reaction of guinea pig skin to topical and subcutaneous administration of four carcinogens administered in different dosages to newborn and adult animals, has been investigated histologically and histochemically. The transplantability of the sarcomas produced, and the occurrence of spontaneous tumours in the strain used, was studied too. The guinea pig was resistant to topical carcinogen treatment, but large doses administered during a long period did induce tumorigenesis. The resulting tumours were all fibrosarcomas. The newborn animals were as resistant as adults. The transplantation of the tumours was successfull, but the percentage of positive “takes” was small. A single dermal tumour occurred spontaneously in the control group consisting of 500 animals.
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Schedule a callMore From: Acta pathologica et microbiologica Scandinavica. Section A, Pathology
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