Homochirality and life.

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After clarifying the frequently misused term homochirality, the crucial importance of homochirality and chiral purity in the development and maintenance of the essential biopolymers of life--proteins and nucleic acids--is discussed. The harsh and forbidding prebiotic environment during the era of cometary impact after formation of the Earth approximately 4.5 Gyr ago is described, after which the most important abiotic mechanisms proposed historically for the genesis of chiral molecules on the primitive Earth are enumerated. Random and determinate terrestrial mechanisms are each evaluated with regard to the environmental restraints imposed during the impact era, and it is concluded that all such mechanisms would be inapplicable and implausible in the realistic prebiotic environment. To circumvent these limitations, an extended hypothesis is presented describing an extraterrestrial source of homochiral terrestrial molecules. Illustrated in Figure 2, this scenario involves the partial asymmetric photolysis of the racemic constituents of organic mantles on interstellar dust grains by the circularly polarized ultraviolet components of the synchrotron radiation emanating from the neutron star remnants of super-novae. The resulting homochiral constituents with low enanantiomeric excesses (e.e.s) so produced in the organic mantles are subsequently conveyed to Earth either by direct accumulation or, more likely, after coalescence into comets or asteroids, followed by repetitive impingement during the impact era. Finally, the low e.e.s of the extraterrestrial homochiral molecules so introduced are amplified by terrestrial autocatalytic or polymerization mechanisms into a state of chiral purity, then are ultimately concentrated and protected by sequestration in the interiors of spontaneously formed protocellular vesicles--there to await further chemical evolution toward the biomolecules of life. Recent observations of the excess of L-over D-amino acids in the Murchison meteorite are cited as validation for the early stages of the proposed hypothesis.