Homochiral Metal-Organic Framework [Co(L)(bpe)2(H2O)2]·H2O Used for Separation of Racemates in High-Performance Liquid Chromatography.

Abstract

A homochiral metal-organic framework (MOF) comprising [Co(L)(bpe)2(H2O)2]·H2O was prepared using (1R,2R)-(-)-1,2-cyclohexanedicarboxylic acid (H2L) and 1,2-bis(4-pyridyl)-ethylene as organic ligands. The homochiral MOF [Co(L)(bpe)2(H2O)2]·H2O was explored as chiral stationary phase (CSP) for high-performance liquid chromatography (HPLC) separation of racemates. Nine racemates including naphthol, alcohol, diol, amine, ketone, ether and organic acid were well separated on the homochiral MOF [Co(L)(bpe)2(H2O)2]·H2O column (250mm long × 4.6mm i.d.). The relative standard deviation for five replicate separations of 1,1'-bi-2-naphthol is 0.69% for the retention time, indicating that the good reproducibility and stability of the homochiral MOF column for HPLC enantioseparation. The results indicated that the homochiral MOF as CSP is practical, which promotes the application of homochiral MOFs in HPLC.