Abstract
Results We obtained more than 100 million short reads per sample. We identified 93 up-regulated genes in unffecteds, and 7 up-regulated genes in affecteds (FDR< 5%). Interestingly, among those DE genes we found some related to endothelial function (HBG1, HBG2, and ADIPOR1), and other related to solute carriers, energetic mechanisms, and apoptosis were also found up-regulared in controls; overexpression of genes involved in inflamation were found in affecteds. We also performed a gene ontology enrichment for the differentially expressed genes (DAVID database) and found eritrocyte and myeloid differentiation processes to be significant (Bonferroni <0.1). Other gene ontologies, like apoptosis or positive regulation of synaptic transmission, showed uncorrected significant P values (<0.05).
Highlights
We performed 52 RNA-seq experiments with 26 controls (20 females) and 26 interictally-drawn samples (20 females) from sex- and age-adjusted patients suffering from migraine with aura (MWA) using Illumina Hi-seq high-throughput sequencing machine
To detect differentially expressed (DE) genes between affected and unaffected samples we used the edgeR software correcting by sex
We identified 93 up-regulated genes in unffecteds, and 7 up-regulated genes in affecteds (FDR< 5%)
Summary
Antecedents There has been only one report analyzing whole blood transcriptome (WBT) in menstrual migraine
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