Abstract
Murine ventricular and atrial KATP channels contain different sulfonylurea receptors (ventricular KATP channels are Kir6.2/SUR2A complexes, while atrial KATP channels are Kir6.2/SUR1 complex). HMR 1098, the sodium salt of HMR 1883 {1-[[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl]-3-methylthiourea}, has been used as a selective sarcolemmal (i.e. SUR2A-dependent) KATP channel inhibitor. However, specificity for ventricular versus atrial channels has not been examined. We used whole-cell patch-clamp techniques on mouse ventricular and atrial myocytes as well as 86Rb+ efflux assays and excised inside-out patch-clamp techniques on Kir6.2/SUR2A and Kir6.2/SUR1 channels heterologously expressed in COSm6 cells.
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