Abstract
In order to define more clearly the importance of the degree of HLA compatibility in the hematologic support of patients refractory to random-donor platelets, we retrospectively analyzed over 1000 platelet transfusions given during stable periods of their disease to 11 thrombocytopenic, severely alloimmunized patients with aplastic anemia: 28% of the donors fully matched with the recipient for HLA A and B loci (A-matched) and 17% of the donors mismatched with the recipient for two or more HLA antigens (D-matched) provided excellent responses, and 18% of A-matched and 46% of D-matched donors provided poor posttransfusion increments. Among all groups analyzed only A-matched donor-recipient pairs had higher increments than predicted by chance (p
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