HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 271 Southeast Asia Indians from Peninsular Malaysia

Ahmad Fauzi Nurul-Aain,Lay-Kim Tan,Hussein Heselynn,Shahril Nor-Shuhaila,Mageswaran Eashwary,Sulaiman Wahinuddin,Ing Soo Lau,Suk Chyn Gun,Mohamed-Said Mohd-Shahrir,Mohd-Mokhtar Ainon,Rosman Azmillah,Othman Muhaini,Murad Shahnaz,Chun-Lai Too

doi:10.1016/j.humimm.2020.04.004

HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 271 Southeast Asia Indians from Peninsular Malaysia

Ahmad Fauzi Nurul-Aain, Lay-Kim Tan + Show 12 more

https://doi.org/10.1016/j.humimm.2020.04.004

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Journal: Human immunology	Publication Date: Apr 18, 2020
Citations: 2

Affiliation: Ministry of Health, Institute for Medical Research, University of Kuala Lumpur, Hospital Selayang, Hospital Tuanku Ja’afar, University Kebangsaan Malaysia Medical Centre, Hospital Tengku Ampuan Afzan, Taiping Hospital, Karolinska Institutet

#Polymerase Chain Reaction Sequence-specific Oligonucleotide #DQB1 Loci + Show 8 more

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Abstract

A total of 271 Southeast Asia Indians from Peninsular Malaysia were genotyped for HLA-A, -B, -C, -DRB1, and -DQB1 loci using polymerase chain reaction sequence-specific oligonucleotide probe hybridization methods. In this report, HLA-B and HLA-DQB1 was in Hardy-Weinberg proportions (HWEP) (p > 0.05). We observed significant deviation from the HWEP for HLA-A (p < 0.05), HLA-C (p < 0.01) and HLA-DRB1 (p < 0.01) loci. This genotype data is available in Allele Frequencies Network Database (AFND) Dos Santos et al. (2016).

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