HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 951 Southeast Asia Malays from Peninsular Malaysia

Lay-Kim Tan,Baharin Mohd-Farid,Sulaiman Salsabil,Hussein Heselynn,Sulaiman Wahinuddin,Ing-Soo Lau,Suk-Chyn Gun,Sharil Nor-Suhaila,M Eashwary,Mohamed Said Mohd-Shahrir,Mohd-Mokhtar Ainon,Rosman Azmillah,Othman Muhaini,Murad Shahnaz,Chun-Lai Too

doi:10.1016/j.humimm.2016.06.022

HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 951 Southeast Asia Malays from Peninsular Malaysia

Lay-Kim Tan, Baharin Mohd-Farid + Show 13 more

https://doi.org/10.1016/j.humimm.2016.06.022

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Journal: Human immunology	Publication Date: Jun 29, 2016
Citations: 11

Affiliation: Institute for Medical Research, Jabatan Perkhidmatan Awam Malaysia, University of Kuala Lumpur, Hospital Raja Perempuan Zainab II, Hospital Selayang, Hospital Tuanku Ja’afar, University Kebangsaan Malaysia Medical Centre, Hospital Tengku Ampuan Afzan, Karolinska Institutet

#DQB1 Loci #Polymerase Chain Reaction Sequence-specific Oligonucleotide + Show 8 more

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Abstract

A total of 951 Southeast Asia Malays from Peninsular Malaysia were genotyped for HLA-A, -B, -C -DRB1, and -DQB1 loci using polymerase chain reaction sequence-specific oligonucleotide probe hybridization methods. In this report, there were significant deviation from Hardy-Weinberg proportions for the HLA-A (p<0.0001), -B (p<0.0001), -DRB1 (p<0.0001) and -DQB1 (p<0.01) loci. Minor deviations from HWEP were detected for HLA-C (p=0.01). This genotype data was available in Allele Frequencies Network Database (AFND) Gonzalez-Galarza et al. (2015).

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