HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 194 Southeast Asia Chinese from Peninsular Malaysia

Chun-Lai Too,Lay-Kim Tan,Hussein Heselynn,Shahril Nor-Shuhaila,Mageswaran Eashwary,Sulaiman Wahinuddin,Ing Soo Lau,Suk Chyn Gun,Mohamed-Said Mohd-Shahrir,Mohd-Mokhtar Ainon,Rosman Azmillah,Othman Muhaini,Murad Shahnaz

doi:10.1016/j.humimm.2019.09.005

HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 194 Southeast Asia Chinese from Peninsular Malaysia

Chun-Lai Too, Lay-Kim Tan + Show 11 more

https://doi.org/10.1016/j.humimm.2019.09.005

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Journal: Human immunology	Publication Date: Sep 23, 2019
Citations: 5

Affiliation: Karolinska Institutet, Ministry of Health, Institute for Medical Research, University of Kuala Lumpur, Hospital Selayang, Hospital Tuanku Ja’afar, University Kebangsaan Malaysia Medical Centre, Hospital Tengku Ampuan Afzan, Taiping Hospital

#Polymerase Chain Reaction Sequence-specific Oligonucleotide #DQB1 Loci + Show 8 more

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Abstract

A total of 194 Southeast Asia Chinese from Peninsular Malaysia were genotyped for HLA-A, -B, -C -DRB1, and -DQB1 loci using polymerase chain reaction sequence-specific oligonucleotide probe hybridization methods. In this report, the HLA-B, HLA-DRB1 and HLA-DQB1 were in Hardy-Weinberg proportions (HWEP) (p > 0.05). We observed significant deviation from HWEP in HLA-A (p < 0.05) and HLA-C (p < 0.01) loci. This genotype data was available in Allele Frequencies Network Database (AFND) Dos Santos et al. (2016).

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